| 세션명 | 대학원생 구두발표 (I) |
|---|---|
| 발표장 | 302호 |
| 논문코드 | 1O11-9 |
| 발표일 | 2019-10-10 |
| 발표시간 | 15:40-15:55 |
| 논문제목 | Acquisition and enhancement of cancer stem cell-like properties in functional poly thin film-induced tumor spheroids |
| 발표자 | 이민석 |
| 발표자 소속 | 한국과학기술원 |
| 저자 | 이민석, 임성갑†, 유승정 |
| 소속 | 한국과학기술원 |
| 논문초록 | Despite of the great attention for developing cancer therapy, especially targeting Cancer Stem Cell (CSC), CSC-related research have been gone through struggles by the limited supply of diverse, patient-derived CSC. Here, we developed polymer thin film (PTF) platform that promotes conversion of cancer cells to cancer stem cells-enriched tumor spheroid which shows highly tumorigenic property without biochemical or genetic manipulations. PTF-induced cancer spheroids showed a significant increase in the expression of CSC-associated genes and exhibited robust drug resistance compared with monolayercultured controls. These spheroids also exhibited highly tumorigenic property in vivo, especially enhanced xenograft tumor-forming ability and metastatic capacity. Our results suggest that by providing a new method of inducing CSC-like tumor spheroids from diverse cancer cells, the PTF platform described here will contribute to CSC-related reseach and drug development. |
THE POLYMER SOCIETY OF KOREA